Research Opportunities


The University of São Paulo Medical School, in collaboration with Hospital das Clínicas (HC), is dedicated to advancing scientific research and standardizing innovative techniques and diagnostic methods. This partnership facilitates the integration of cutting-edge advancements into patient care across HC institutes.

FMUSP comprises 17 departments, each playing a vital role in the institution's mission to excel in medical education, research, and healthcare delivery. These departments encompass a wide array of specialties and disciplines, ensuring comprehensive coverage across the medical spectrum. From basic sciences to clinical practice and public health, each department contributes uniquely to FMUSP's multifaceted approach to advancing medicine.

Below, you will find further details regarding the primary research domains of some of the departments within FMUSP. These areas represent the forefront of medical innovation and discovery, shaping the future of healthcare:

1. CARDIOLOGY

Description: This research line focuses on physiological and clinical diagnostics through imaging in cardiology, reflecting extensive experience in internal medicine, cardiology, and intensive therapy. Additionally, there is a particular interest in areas such as Magnetic Resonance Imaging and the Heart. This area represents a vital field for advancing the diagnosis and treatment of cardiovascular diseases, significantly contributing to modern cardiovascular medicine.

Main Research areas:  Magnetic Resonance Imaging and Heart

Researchers: Roberto Kalil Filho

Contact: cardiopneumo@usp.br

2. CARDIO-ONCOLOGY

Description: Cardio-oncology addresses the complex interactions between cardiovascular diseases and cancer, a critical specialty considering that cancer treatment can have significant effects on the heart and vascular system. A study conducted by the Cancer Institute of the State of São Paulo, under the leadership of Prof. Kalil and his team, highlighted the prevalence of cardiovascular risk factors in cancer patients, as well as the impact of treatment-induced cardiotoxicity. This 10-year study emphasized the importance of monitoring and effectively treating the cardiotoxic effects of cancer therapies to improve patient outcomes.

Main Research areas: Cardiology and Oncology

Researchers: Roberto Kalil Filho, Ludhmila Hajjar

Contact: cardiopneumo@usp.br

3. MECHANOTRANSDUCTION IN THE VASCULAR SYSTEM

Description: Determining how endothelial and vascular smooth muscle cells respond to physical forces present in the cardiovascular system (pressure, stretching, and shear stress). Hemodynamic changes directly influence vascular functions and are associated with the genesis of cardiovascular diseases. Combining concepts from physics and biology, multidisciplinary approaches are used to break down this complex problem and identify new therapeutic interventions.

Main Research areas:  Biological Sciences, Physiology, Organ and Systems Physiology, Cardiovascular Physiology

Researchers: José Eduardo Krieger, Ayumi Aurea Miyakawa, Miriam Helena Fonseca-Alaniz 

Contact: cardiopneumo@usp.br

4. STUDY OF THE GENETIC ARCHITECTURE OF CARDIOVASCULAR DISEASES

Description:  Identifying genetic determinants of cardiovascular diseases to understand how they interact with each other and with environmental factors in determining complex phenotypes. The identification of genetic determinants and their contribution to the development of these phenotypes have been applied in machine learning methodologies for the development of predictive models that can help in the early identification and stratification of these patients for new lines of care.

Main Research areas:  Biological sciences, genetics, animal genetics

Researchers: José Eduardo Krieger, Alexandre da Costa Pereira, Samantha Kuwada Teixeira, Layara, Fernanda Vicente Pereira Lipari, Lucas Vieira Lacerda Pires, Bruno Moreira dos Santos, Vinícius Machado Correia, Bianca Domit Werner Linnenkamp, Fernando Rabioglio Giugni, Silas Ramos Furquim, Fernanda Almeida Andrade, Natália Quintella Sangiorgi Olivetti.

Contact: cardiopneumo@usp.br

5. BIOLOGICAL CARDIAC REPAIR POST-INFARCTION

Description: Reconstructing the microenvironment of cardiac tissue post-infarction using the transplantation of pluripotent adult cells and/or their products to preserve cardiac function and replace cardiomyocytes through the transplantation of cardiomyocytes derived from induced pluripotent stem cells (hiPSC-CMs) to restore organ contractile capacity. These strategies are being tested through a combination of in vitro approaches, pre-clinical studies with small and medium-sized animals, and clinical trials with humans.

Main Research Areas: Biological sciences, genetics, cellular therapy, and gene therapy.

Researchers: José Eduardo Krieger, Elida Adalgisa Neri

Contact: cardiopneumo@usp.br

1. UNIVENTRICULAR HEARTS: CARDIOVASCULAR, LYMPHATIC, PULMONARY, AND MUSCULOSKELETAL SYSTEMS

Description: We have developed projects aimed at investigating how cardiovascular adaptations in patients with a single functional ventricle affect other systems, such as the lymphatic, pulmonary, and musculoskeletal systems. Additionally, we aim to develop and optimize surgical interventions and clinical treatments that improve the function and quality of life of these patients, as well as to design rehabilitation and exercise programs that are safe and effective in improving functional capacity and reducing long-term complications.

Main Research areas: Cardiopulmonary Rehabilitation, Surgery for Congenital Heart Disease Correction

Researchers: Marcelo Biscegli Jatene, Luiz Fernando Caneo, Aida Luiza Ribeiro Turquetto e Luciana, Patrick Amato

Contact: cardiopneumo@usp.br

2. ASSISTED DIGITAL TELEMONITORING WITH WEARABLES IN PATIENTS POST-CARDIOVASCULAR SURGERY

Description: Remote patient monitoring through wearables represents a significant advancement in healthcare, bringing along a range of essential benefits. The use of these devices promotes patient engagement in their health care, encouraging the adoption of healthy habits and regular monitoring of their medical conditions. Additionally, remote monitoring enables early detection of complications, including arrhythmias, allowing for quick and effective intervention. It also has an important contribution to early discharge, with continuous real-time monitoring of vital signs and health parameters, reducing hospital stay and associated risks of prolonged hospitalization, ensuring more personalized, efficient, and safe care. 

Main Research areas: Post-operative remote monitoring, wearables, hospital discharge

Researchers: Fabio Biscegli Jatene, Rosangela Monteiro, Guilherme Rabello

Contact: cardiopneumo@usp.br

1. EMERGENCY MEDICINE INTENSIVE CARE MEDICINE

Description: This discipline focuses on the treatment of critically ill patients, especially those at high risk. This includes triage, risk classification, and the approach to catastrophes, circulatory shock, septic shock, cardiogenic shock, stroke, respiratory failure, difficult airway, major burns, among others in urgent and emergency contexts.

Main Research areas: Emergency medicine, intensive care/cardiology aiming to improve medical practices and outcomes for critically ill patients. 

Researchers: Ludhmila Abrahão Hajjar

Contact: deptoclinicamedica.ichc@hc.fm.usp.br

1.SOLID TUMORS

Description: The main objective is the development of new therapies for the treatment of solid tumors through clinical trials with interventions from phase I to IV. Additionally, this research line includes projects involving real-world data, implementation of structured cancer registries, and the study of predictive tumor biomarkers for response and/or resistance to oncological treatment.

Academic studies developed by such projects include:

1) Pertuzumab, trastuzumab, and chemotherapy in HER2-positive gastric/gastroesophageal junction cancer: end-of-study analysis of the JACOB phase III randomized clinical trial

This study examined the efficacy of pertuzumab, trastuzumab, and chemotherapy in the treatment of advanced HER2-positive gastric/esophagogastric junction cancer. Although the study did not achieve its primary objective, it demonstrated some activity of the dual anti-HER2 blockade combination in this setting and contributed to a better understanding of the therapeutic management of the disease

2) Gastric cancer molecular classification and adjuvant therapy: Is there a different benefit according to the subtype?

This study analyzed the effect of treatment on different molecular subtypes of gastric cancer. It was found that patients with a specific subtype (p53-aberrant) significantly benefited from chemotherapy, while other subtypes did not show improved survival with treatment. This highlights the importance of personalized treatment strategies based on molecular analysis for gastric cancer.

3) Radiotherapy-induced malignancies in breast cancer patients with TP53pathogenic germline variants (Li-Fraumeni syndrome)

This study evaluated the outcomes of patients with pathogenic variants of the TP53 gene treated for localized breast cancer in a Brazilian cohort. Sixteen patients were assessed to analyze the development of radio-induced tumors in this population. After a median follow-up of 52.5 months, two patients (16.6%) developed radiotherapy-induced malignancies (RIMs). This study underscores the importance of early diagnosis of hereditary syndromes associated with early breast cancer for careful therapeutic management planning in such patients.

4) Young-age onset colorectal cancer in Brazil: analysis of incidence, clinical features and outcomes in a tertiary cancer center

This retrospective study analyzed 780 patients with colorectal cancer (CRC) diagnosed under the age of 50 between January 2011 and November 2016. An absolute increase in CRC incidence in this age group from 1.88% to 2.23% annually was observed, with a relative increase of 35.3% during the study period.This data provides important epidemiological information regarding cancer in the Brazilian population, highlighting age-related changes observed in recent years.

5) Outcomes of Patients With Local Regrowth After Nonoperative Management of Rectal Cancer After Neoadjuvant Chemoradiotherapy

This study examines the outcomes of the 'watch-and-wait' strategy in rectal cancer patients after chemoradiotherapy. It was found that around 30% of patients adopting this strategy experienced local recurrence, on average 14.2 months after initial treatment. All recurrence cases were treated with sphincter-preserving salvage surgery; however, the five-year overall survival was lower for the recurrence group compared to patients maintaining sustained complete clinical response.

6) ANTARES Study - Phase II basket study to evaluate tissue-agnostic efficacy of anti-PD1 monoclonal antibody in patients with advanced rare tumors

This is a prospective, interventional, phase II, multicenter 'basket' study. Patients with advanced or metastatic rare malignant neoplasms expressing PD-L1 defined as CPS score greater than or equal to 10 who progress on approved standard treatments available in prior lines will receive systemic treatment with anti-PD1 antibody.

7) Development of diagnostic test and Dynamic evaluation of ctDNA in patients with cervical and anal canal tumors for optimization of follow-up and clinical outcomes in the SUS

This two-phase study aimed to develop a ctDNA test locally at ICESP and evaluate early immunotherapy in patients with incomplete response after definitive treatment with CT/RDT. The HPV ctDNA research test has potential for future inclusion in the Unified Health System. Dynamic ctDNA research could serve as a biomarker to identify disease progression risks and guide therapy intensification in high-risk recurrence patients. Early immunotherapy for patients with persistent ctDNA after definitive treatment may increase cure rates and overall survival.

Main Research areas:  Gastrointestinal Tract Tumors, Gynecological Tumors, Genitourinary Tract Tumors, Lung, Head and Neck Tumors, Breast Cancer, Rare Tumors, Hereditary Cancer, Pharmacology, and Pharmacogenomics in Oncology.

Researchers: Paulo Hoff, Angelita Gamma

Contact: departamento.inrad@hc.fm.usp.br

1. DERMATOLOGY

Description: The graduate program in Dermatology aims the training of professors and researchers who will work in the various areas of Health Sciences such as Medicine, Biomedicine, Biological Sciences, Pharmaceutical Sciences, among others. Dermatology is a clinical and interventional specialty, with peculiar characteristics; It comprises the study of basic areas of knowledge such as Morphology, Physiology, Genetics, Immunology, Microbiology and Pathology, as well as the interaction with interface areas such as Internal Medicine, Infectious Diseases, Oncology, Allergy and Immunology and Plastic Surgery. 

Main Research areas:

1- Skin Allergy: This research focuses on studying allergic diseases, particularly their high frequency in the population leading to conditions like asthma, rhinitis, and significant skin reactions. Understanding the underlying pathophysiological mechanisms is crucial for improving diagnosis and developing new therapeutic approaches such as targeted therapies and vaccines.

2- Cutaneous Autoimmunity: Investigating autoimmune and inflammatory diseases with skin manifestations is important, as they can often be early indicators of broader systemic disorders. A deeper understanding of the immunopathogenesis of these conditions can lead to innovative diagnostic and therapeutic methods.

3- Cutaneous Tissue Response: This research aims to expand our knowledge of how the skin responds in terms of expression, signaling, and immunomodulation during various pathological processes. Insights gained here could pave the way for the development of novel drugs and diagnostic tools.

4- Infectious and Parasitic Dermatoses: This line of research delves into the pathogenetic mechanisms behind infectious and parasitic skin diseases, including their epidemiological and environmental triggers. Emphasis is placed on dermatoviruses, bacterial, fungal, and parasitic infections prevalent in specific environments.

5- Genodermatoses: These are inherited skin disorders with significant impact due to their severity, extracutaneous effects, physical impairments, premalignant lesions, and susceptibility to early neoplasms. Enhancing clinical and laboratory characterization of genodermatoses is crucial given their rarity and complexity.

6- Interventional Methods in Dermatological Therapy: This research analyzes the efficacy of new interventional techniques (e.g., laser therapy, Mohs surgery, cryotherapy) in treating inflammatory and neoplastic skin conditions. Understanding their impact on disease progression is essential for optimizing dermatological therapies.

7- Cutaneous Oncology: This area encompasses research on malignant skin tumors like basal cell carcinoma, squamous cell carcinoma, melanomas, cutaneous lymphomas, and other benign/malignant integumentary neoplasms. The focus is on epidemiology, clinical aspects, immunohistopathology, diagnosis, and therapeutic strategies, promoting interdisciplinary collaboration.8- Pandemics: Investigating genetic polymorphisms, pro-inflammatory cytokines, antibody responses, and signaling pathways in COVID-19 patients can provide insights into disease severity, therapeutic targets, and future treatment approaches. This research contributes to our understanding and management of COVID-19 infections.

8- Pandemics: Investigating genetic polymorphisms, pro-inflammatory cytokines, antibody responses, and signaling pathways in COVID-19 patients can provide insights into disease severity, therapeutic targets, and future treatment approaches. This research contributes to our understanding and management of COVID-19 infections.

Researchers:

1. Alberto José da Silva Duarte: 1,2,8

2. Carlos Pelleschi Taborda: 3,4

3. Cyro Festa Neto: 3,7,8

4. Dewton de M. Vasconcelos: 1,2,5

5. Edileia Bagatin: 3,6

6. Gil Benard: 1,2,4,8

7. Gilda Del Negro: 1,4 8

8. Jade Martins-Cury: 4,7

9. Jorge Simão do Rosário Casseb: 1,4,7,8

10. José Antonio Sanches Jr: 3,7,8

11. Juarez Quaresma: 4,7,8

12. Luis Antonio Torezan: 3,6

13. Marcello Menta Nico: 2,4,5,7

14. Maria da Gloria S. Sousa: 4,8

15. Maria N Sato: 1,2,3,8

16. Mirian N Sotto: 2,3,4,7,8

17. Paulo R Criado: 2,4,7,8

18. Raquel Leão Orfali: 1,2,3,8

19. Ricardo Romiti: 1,3

20. Valéria Aoki: 1,2,3,8

21. Zilda N. P. Oliveira: 3,5

Contact: dermatologia.ichc@hc.fm.usp.br

1.GENETIC AND EPIGENETIC STUDIES OF REPRODUCTIVE ENDOCRINE DISORDERS

Description: In this research project, we gather six original proposals of genetic and epigenetic studies, utilizing robust and advanced methodologies in large patient cohorts with disorders characterized by central or peripheral (autonomous) hyperactivation of the reproductive axis, including familial and sporadic central precocious puberty, peripheral precocious puberty due to ovarian autonomy (McCune-Albright syndrome), and polycystic ovary syndrome.

Main Research areas: Precocious Puberty, Genetics, Hypogonadism

Researchers: Vinicius Nahime Brito, Ana Cristina Victorino Krepischi ; Larissa Garcia Gomes ; Luciana Ribeiro Montenegro ; Nadja Cristhina de Souza Pinto ; Niels Olsen Saraiva Câmara; Ursula B Kaiser (Boston, U.S.A) e Jesús Argente ( Madrid, Spain).

Contact: deptoclinicamedica.ichc@hc.fm.usp.br


1. PHYSICAL MEDICINE AND REHABILITATION

Description: Priorities include removing barriers and increasing access to health services and programs; strengthening and extending rehabilitation from primary care levels to high complexity care, including assistive technologies and support services; enhancing the collection of relevant and internationally comparable data on disabilities and supporting research on disability and related services.

Main Research areas: Strengthening, Rehabilitation, and Research

Researchers: Linamara Rizzo Battistella

Contact: mls@fm.usp.br

2. WORLD REHABILITATION ALLIANCE – WRA

Description: The WRA is a network of organizations dedicated to supporting the implementation of the 'Rehabilitation 2030' initiative through awareness and advocacy activities. IMREA is involved in all working groups established by WRA, including integrating rehabilitation into primary health care, strengthening the rehabilitation workforce, integrating rehabilitation into emergency services, and promoting rehabilitation research. The working group meetings have produced action plans that will be implemented by each group over the next two years.

Main Research areas: Strengthening, Rehabilitation, and Research

Researchers: Marta Imamura

Contact: mls@fm.usp.br

3. INHIBITORY DEFICIT AS A MARKER OF NEUROPLASTICITY IN REHABILITATION - SPEC - São Paulo Excellence Chair - Partnership With Harvard Medical School

Description: This project aims to gain a better understanding of the neuroplasticity mechanisms involved in rehabilitation and develop transdiagnostic neurophysiological biomarkers, which will be highly relevant for the scientific and therapeutic improvement of rehabilitation.

Main Research areas: Biomarkers, Rehabilitation, Electroencephalography, Neuroplasticity, Transcranial Magnetic Stimulation"

Researchers: Linamara Rizzo Battistella, Marta Imamura, André Tadeu Sugawara

Contact: mls@fm.usp.br

4. ULTRASOUND TRAINING FOR SARCOPENIA AND KNEE OSTEOARTHRITIS ASSESSMENT - being developed with the Department of Physical Medicine and Rehabilitation - Faculty of Medicine at Hacettepe University - Ankara, Turkey

Description: This theoretical and practical training aims to educate physiatrists who will participate in two separate projects regarding ultrasound (US) assessment of individuals with sarcopenia and knee osteoarthritis. Participants will initially receive educational materials summarizing technical aspects. After attending face-to-face lectures, they will also have the opportunity to practice under supervision. Finally, patients will be enrolled and assessed by the instructor, as well as by interns to confirm optimal measures.

Main Research areas: Rehabilitation, sarcopenia, education

Researchers: Marta Imamura

Contact: mls@fm.usp.br

5. INTERNATIONAL COOPERATION PROGRAM: DEPARTMENT OF PHYSICAL AND REHABILITATION MEDICINE. Hacettepe University Medical School. Ankara, Turkey.

Description: This research constitutes part of the development of an international cooperation project aiming at a multicenter study including international cooperation for standardized data collection of knee ultrasonography in primary knee osteoarthritis patients and systematic research of sarcopenia in patients with knee osteoarthritis and ischemic stroke.

Researchers: Marta Imamura.

Contact: mls@fm.usp.br

6. ASSISTIVE TECHNOLOGY RESEARCH, in partnership with the University of London

Description: Investigation of the access to assistive technology, including related products and services, its integration into the healthcare system, adopted care models and normative strategies, as well as advances in digital technologies.

Main Research areas: Health technology; disability and rehabilitation; health equity.

Researchers: Linamara Rizzo Battistella e Vinicius Delgado Ramos

Contact: mls@fm.usp.br

7. BLOOMBERG PROJECT - Bloomberg Initiatives for Global Road Safety in São Paulo

Description: The research project aims to collect data on the main risk factors for traffic accidents, which include: helmet use by motorcyclists, seat belt use by drivers and vehicle passengers, speeding, and drinking and driving. 

Researchers: Vilma Leyton, Heráclito Barbosa de Carvalho

Contact: mls@fm.usp.br

8. OPTIMIZATION OF GAIT REHABILITATION IN SPINAL CORD INJURY USING EEG BETA OSCILLATIONS AS A MARKER OF RECOVERY, through the National Institutes of Health (NIH) of the United States.

Description: This research project aims to test a biomarker for sensorimotor cortex plasticity, EEG beta oscillations, during traditional rehabilitation treatment to answer the following questions:

- Can beta EEG oscillations be used to predict the success of rehabilitation treatment?

- Can EEG beta oscillations inform early in treatment about the future success of rehabilitation treatment?

- Can EEG beta oscillations inform whether subjects will respond with a recovery pattern versus compensation pattern?

Researchers: Marcel Simis, Elif Uygur-Kucukseymen, Kevin Pacheco-Barrios, Linamara Rizzo Battistella, Felipe Fregni

1. MOLECULAR AND CELLULAR PATHOGENESIS OF GENETIC KIDNEY DISEASES

Description: Research profile includes

1. Projects aimed at the molecular and cellular pathogenesis of autosomal dominant polycystic kidney disease using mouse and cellular models with different profiles of Pkd1 gene deficiency.

2. Project focused on the development of renal cysts and vascular phenotypes potentially associated with variants in the PKD1 or PKD2 genes.

3. Project focused on the genetic-molecular pathogenesis of autosomal dominant tubulointerstitial kidney disease.

4. Projects aimed at the genetic-molecular pathogenesis of pediatric and adult human glomerulopathies.

5. Projects aimed at proteomic analysis in human glomerulopathies.

Main Research areas: Autosomal Dominant Polycystic Kidney Disease, Autosomal Dominant Tubulointerstitial Kidney Disease, Collapsing Glomerulopathy, Pediatric Nephrotic Syndrome, Renal Amyloidosis

Researchers: Luiz Fernando Onuchic, Elieser Hitoshi Watanabe, Andreia Watanabe, Precil Diego Miranda de Menezes Neves

Contact: deptoclinicamedica.ichc@hc.fm.usp.br

1. COGNITIVE DECLINE IN TYPE 2 DIABETES MELLITUS MANAGED IN PRIMARY HEALTH CARE: ASSOCIATION WITH OTHER COMPLICATIONS AND SEARCH FOR BIOMARKERS FOR PREDICTION ALGORITHM DEVELOPMENT

Description: A preliminary analysis of 350 individuals revealed the need for optimizing T2DM treatment and other comorbidities, as well as adopting measures to delay progression to dementia, such as physical activity programs and dietary adjustments. Microangiopathy is responsible for the following complications: diabetic kidney disease (2nd cause of admission to dialysis programs in Brazil), retinopathy (an important cause of blindness), distal neuropathy (cause of amputations) and cardiovascular autonomic neuropathy (which increases mortality). DM2 also increases the risk of Alzheimer's disease and vascular dementia. In addition to affecting the quality of life of the individual and their family, cognitive decline (CD) compromises the ability to understand, necessary for the treatment of DM.

Main Research areas: Neurology, Endocrinology, Public Health Management

Researchers: Suely Kazue Nagahashi Marie, Maria Lucia Correa-Giannella, Marisa Passarelli, Giuseppe palmisano, Antonio Marcondes Lerario (Univ Michigan), Miriam Shirassu (Secretaria do Estado da Saude de SP)

Contact: elizabeth.lauritano@hc.fm.usp.br

2. PREVENTION OF BLINDNESS BY SCREENING FOR DIABETIC RETINOPATHY

Description: Retinopathy, a complication of diabetes, affects approximately 36.2% of individuals in Brazil, ranking as a leading cause of blindness in the country. Detecting and treating diabetic retinopathy (DR) early is crucial, especially for those at risk of vision loss, who may benefit from laser therapy to prevent blindness. However, Brazil currently lacks a national screening program for DR. Therefore, this project aims to address this gap by focusing on preventing DR-related blindness in underserved areas of Brazil. Nurses will conduct population-wide screenings using retinal cameras attached to cell phones. Individuals with vision-threatening DR will then be referred to ophthalmology centers for laser therapy. This collaborative project will be implemented in Brazil, in partnership with the University of São Paulo School of Medicine.

Main Research areas: Neurology, Endocrinology, Public Health Management

Researchers: Suely Kazue Nagahashi Marie, Maria Lucia Correa-Giannella, Marisa Passarelli, Giuseppe palmisano, Antonio Marcondes Lerario (Univ Michigan), Miriam Shirassu (Secretaria do Estado da Saude de SP)

Contact: elizabeth.lauritano@hc.fm.usp.br

3. SEARCHING DETERMINANT TARGETS FOR BRAIN TISSUE REGENERATION AFTER TRAUMATIC BRAIN INJURY

Description: Traumatic brain injury (TBI) poses significant epidemiological and social challenges, especially in low- and middle-income countries like Brazil, where effective treatments are lacking. Current clinical and surgical interventions are based on established models, highlighting the critical need for a deeper understanding of patient progression, long-term functional outcomes, clinical predictors, and molecular mechanisms involved in TBI.

This ongoing study involves systematic sample collection to validate these initial findings in a larger cohort and assess brain tissue changes mirrored in extracellular vesicles (EVs) isolated from peripheral fluids like plasma and saliva. Identifying biomarkers in biological samples will enable monitoring TBI patients for functional recovery and guiding therapeutic decisions.

Main Research areas: Traumatic brain injury by multidisciplinary evaluation, multiomic analysis of contusional tissue and liquid biopsy in traumatic brain injury, TBI animal experimental model, new therapeutic strategies  for TBI

Researchers: Wellingson Silva Paiva, Luiz Marcelo Malbuilssom, Almir Ferreira de Andrade, Suely Kazue Nagahashi Marie, Giuseppe Palmisano, Luiz Eugênio de Mello, Marcondes lerario (Univ Michigan), Angelos georgiou Kolias (Univ Cambridge), Peter John Hutchinson (Univ Cambridge).

Contact: elizabeth.lauritano@hc.fm.usp.br

1. MORPHOLOGICAL, BIOCHEMICAL, MOLECULAR, IMMUNOLOGICAL, AND CLINICAL ANALYSIS OF THE REPRODUCTIVE SYSTEM IN FERTILE AND INFERTILE WOMEN. EXPERIMENTAL AND CLINICAL STUDIES

Description: This translational research line focuses on experimental and clinical studies on fertility and infertility in women, covering morphological, biochemical, molecular, and immunological analyses. It investigates new diagnostic and prognostic methods for conditions such as endometriosis, polycystic ovary syndrome, and human reproduction. Additionally, it studies Climacteric, a crucial phase in women's lives, exploring physiopathological changes and new therapies, with morphological, biochemical, and molecular analyses to advance knowledge in this field, including aspects related to sexuality during this phase of life.

Researchers: Edmund Chada Baracat ; Gustavo Arantes Rosa Maciel; lara Moreno Linhares; Isabel Cristina Esposito Sorpreso; Kátia Cândido Carvalho; José Maria Soares Júnior; Maurício Simões Abrão.

Contact: secdepto.og@usp.br / fátima.abdul@hc.fm.usp.br / fatima.abdul@usp.br

2. STUDY OF DETERMINANTS OF MATERNAL AND FETAL OUTCOMES AND THE IMPACT OF PREGNANCY ON ADULT HEALTH

Description: This research line covers challenges in maternal and child health, aligning with the Sustainable Development Goals (SDG 3). It focuses on identifying markers to reduce maternal and fetal morbidity and mortality, conducting epidemiological and clinical studies, analyzing biomarkers and cohorts to better understand the impact of pregnancy on women's and children's health. It also studies abnormalities in fetal development, investigating epidemiological, genetic, and molecular aspects to propose new diagnostic, treatment, and prognostic tools. Additionally, it applies Data Science to Obstetrics and Gynecology using advanced data analysis, AI, and machine learning to improve understanding and prevention of conditions associated with women's health. This integrated approach aims to promote maternal and child health significantly.

The research line in maternal and child health is crucial for the Sustainable Development Goals (SDG 3), especially regarding maternal and fetal health. The main focus is to find diagnostic and prognostic markers to reduce morbidity and mortality in these areas. Epidemiological and clinical studies are conducted, analyzing new biomarkers and cohorts to better understand the impact of pregnancy on women's and children's health, with these studies useful for guiding public policies.

Abnormalities in fetal development are associated with high rates of infant mortality, especially in the perinatal period. This research line compares normal fetuses with those with morphofunctional alterations, exploring epidemiological, genetic, and molecular aspects to propose new diagnostic, therapeutic, and prognostic approaches. These studies are crucial for understanding the physiology and pathophysiology of these conditions and are relevant for guiding public policies.

The research line in Applied Data Science to Obstetrics and Gynecology aims to develop analytical methods to improve the understanding, diagnosis, treatment, and prevention of conditions related to women's health. Using advanced data analysis techniques, artificial intelligence, and machine learning, this interdisciplinary area extracts valuable insights from complex data sets, covering both Obstetrics and Gynecology. These advancements have the potential to significantly improve clinical practice in these areas.

Researchers: Rossana Pulcineli Vieira Francisco; Maria de Lourdes Brizot; Agatha Sacramento Rodrigues; Mariana Azevedo Carvalho; Mario Henrique Burlacchini de Carvalho; Rafaela Alkmin da Costa; Fábio Roberto Cabar; Agatha Sacramento Rodrigues; Marco Aurélio Knippel Galetta.

Contact: secdepto.og@usp.br / fátima.abdul@hc.fm.usp.br / fatima.abdul@usp.br

1. DEVELOPMENT OF TESTS AND MODELS FOR JOINT REPLACEMENT AND JOINT INSTABILITY

Description: Clinical, surgical, and experimental studies involving the replacement of segments and analysis of joint stability in the musculoskeletal system. Includes investigations on substitute materials, replacement procedures and their effects, and joint stabilizing structures.

Main Research areas: Orthopedic Subspecialties - Foot, Knee, Hip, Hand, Orthopedic Oncology.

Researchers: Alexandre Leme Godoy dos Santos, Marco Kawamura Demange, Camilo Partezani Helito e Riccardo Gomes Gobbi, Henrique Campos de Melo Gurgel, Rames Mattar Junior, Marcelo Rosa de Rezende, Teng Hsiang Wei, Olavo Pires de Camargo

Contact: sec.dot.iot@hc.fm.usp.br / rosana.costa@hc.fm.usp.br

2. DEGENERATIVE, INFLAMMATORY, AND STRUCTURAL DISORDERS OF THE LOCOMOTOR SYSTEM

Description: Etiopathogenic, clinical, laboratory, imaging evaluation of degenerative, inflammatory, traumatic, neoplastic, and infectious processes. Study of the structure of organs and tissues of the locomotor system, including their functional and morphological properties.

Main Research areas:  Orthopedic Subspecialties - Spine, Hand, Infection, Knee, Trauma, Pediatric Orthopedics, Orthopedic Oncology.

Researchers: Tarcisio Eloy Pessoa de Barros Filho, Alexandre Fogaça Cristante, Raphael Martus Marcon, Ana Lucia Lei Munhoz Lima, Marco Kawamura Demange, Camilo Partezani Helito, Riccardo Gomes Gobbi, Rames Mattar Junior, Marcelo Rosa de Rezende, Teng Hsiang Wei, Eduardo Angeli Malavolta, Kodi Edson Kojima, Patricia Moreno Grangeiro, Olavo Pires de Camargo

Contact: sec.dot.iot@hc.fm.usp.br / rosana.costa@hc.fm.usp.br

1. DEVELOPMENTAL ORIGINS OF HEALTH AND DISEASE

Description: Study of interactions between the environment and cellular, physiological, metabolic, and epigenetic mechanisms during growth and development, from the fetal period to adolescence, identifying risk factors for chronic adult diseases.

Research project: “Clinical evolution of newborns from mothers with COVID-19 in a tertiary hospital in Brazil."

Contact: adriana.trindade@hc.fm.usp.br

2. EXPERIMENTAL MODELS OF CLINICAL AND SURGICAL

Description: Implementation of experimental models of surgical conditions in children and liver transplantation, for a greater understanding of physio-pathological mechanisms and proposal of new treatments

Research project: Model of liver regeneration in young rats subjected to partial hepatectomy with enterectomy: Histological and molecular studies.

Contact: adriana.trindade@hc.fm.usp.br

3. PUBLIC HEALTH POLICIES TO IMPROVE CHILD AND ADOLESCENT HEALTH

Description: This research line encompasses projects that formulate and analyze health programs and policies for childhood and adolescence.

Research project: Improving the quality of the national early childhood development program ‘Criança Feliz’

Contact: adriana.trindade@hc.fm.usp.br

4. CHILD IMMUNE RESPONSE AND CONGENITAL AND ACQUIRED DISORDERS

Description: Understanding the mechanisms of the child's physiological immune response and its disorders, enabling early identification of autoimmune diseases and primary immunodeficiencies.

Main Research areas: Early-onset autoimmune diseases,Thymus functions and central tolerance.

Contact: adriana.trindade@hc.fm.usp.br

5. CLINICAL AND EPIDEMIOLOGICAL ASPECTS OF RESPIRATORY AND INFECTIOUS DISEASES IN PEDIATRICS

Description: Study of factors influencing the development and progression of these diseases, for the development of prevention and treatment strategies.

Research project: clinical and diagnostic aspects of infectious diseases in children and adolescents

Contact: adriana.trindade@hc.fm.usp.br

6. MECHANISMS OF ANTI-INFECTIOUS RESISTANCE AND TROPHIC FACTORS OF HUMAN MILK

Description: Study of the immune components of human milk that have anti-infectious activity and trophic factors.

Research project: Development of Intestinal Microbiota and clinical evolution in Very Low Birth Weight Newborns fed with human milk or formula in a Tertiary Care Intensive Care Unit

Contact: adriana.trindade@hc.fm.usp.br

7. THERAPEUTIC INTERVENTIONS IN PEDIATRIC DISEASES

Description: Study of therapeutic interventions in pediatric diseases, pharmacological or non-pharmacological, evaluating indications and outcomes, from ambulatory patients to critically ill ones.

Research project: Critical evaluation of the use of inotropes in the tertiary neonatal intensive care unit.

Contact: adriana.trindade@hc.fm.usp.br

8. DIAGNOSTIC AND PROGNOSTIC MARKERS OF PEDIATRIC DISEASES

Description: Study of markers aimed at early diagnosis, genetics, therapeutic response, and survival in pediatric diseases. It also involves the study of the latest laboratory methodologies, such as molecular diagnosis.

Research project: Rare Genomes: Genomic Application for the Diagnosis of Rare Diseases and Hereditary Risk in Brazil.

Contact: adriana.trindade@hc.fm.usp.br

9. CHRONIC DISEASES IN CHILDREN AND ADOLESCENTS: IMPACT ON PHYSICAL, PSYCHIC HEALTH, AND SOCIAL RELATIONSHIPS

Description:  Study of the impact of chronic diseases and treatment, assessing the sequelae of the disease and/or treatment, as well as interference in the patient's quality of life and their social circle.

Research project: Evaluation of the quality of life of children and their families with chronic diseases.

Contact: adriana.trindade@hc.fm.usp.br

10. CLINICAL AND SOCIODEMOGRAPHIC ASPECTS OF CHILD DEVELOPMENT.

Description: Studies focused on the impacts of adversity during early childhood and their reflections on development and behavior, and creation of metrics for assessing child development.

Research project: Creation and validation of the Global Scale of Child Development (GSED-WHO).

Researchers:

Adriana Maluf Elias Sallum, Alexandra Valeria Maria Brentani, Alexandre Archanjo Ferraro, Amélia Gorete Afonso da Costa Reis, Ana Cristina Aoun Tannuri, Ana Paula Beltran Moschione Castro, Ana Paula Scoleze Ferrer, Artur Figueiredo Delgado, Chong Ae Kim, Cintia Johnston, Claudio Schvartsman, Clovis Artur Almeida da Silva, Débora Romeo Bertola, Edna Maria de Albuquerque Diniz, Gabriela Nunes Leal, Heloísa Helena de Sousa Marques, Juliana Caires de Oliveira Achili Ferreira, Leslie Domenici Kulikowski, Lilian Maria Cristofani, Louise Cominato, Lúcia Maria Mattei de Arruda Campos, Luiz Vicente Ribeiro Ferreira da Silva Filho, Magda Maria Sales Carneiro Sampaio, Maria Fernanda Bádue Pereira, Maria Teresa Bechere Fernandes, Patricia Palmeira Daenekas Jorge, Patricia Zamberlan dos Santos, Ricardo Katsuya Toma, Sandra Elisabete Vieira, Sylvia Costa Lima Farhat, Thelma Suely Okay, Thomaz Bittencourt Couto, Vera Lúcia Jornada Krebs, Vicente Odone Filho, Werther Brunow de Carvalho


Contact: adriana.trindade@hc.fm.usp.br

 1. INTERSTITIAL LUNG DISEASES

Description: Study of lower respiratory tract diseases characterized by alveolar disruption and functional loss of the alveolocapillary unit. Pathophysiology, diagnosis, and treatment.

Main Research areas: Cystic lung diseases, autoimmune diseases, hypersensitivity pneumonitis, lymphocytic lung diseases, sarcoidosis, fibrosing lung diseases, alveolar proteinosis.

Researchers: Bruno Guedes Baldi, Carlos Roberto Ribeiro Carvalho, Ronaldo Adib Kairalla 

Contact: cardiopneumo@usp.br

1. MULTIMODAL IMAGING ASSESSMENT OF BRAIN AGING AND DEMENTIAS

Description: This research line investigates findings related to normal brain aging and those of patients with cognitive decline and dementia using various techniques such as high-field magnetic resonance imaging (MRI), PET, and SPECT, both qualitatively and quantitatively. The goal is early diagnosis of cognitive disorders. Additionally, with the consolidated database, the aim is to apply artificial intelligence techniques to distinguish between normal and pathological brain conditions.

Main Research areas: Radiology, Nuclear Medicine, Innovation

Researchers: Claudia da Costa Leite, Carlos Alberto Buchpiguel, Giovanni Guido Cerri

Contact: departamento.inrad@hc.fm.usp.br

2. TRANSLATIONAL RESEARCH EMPHASIZING DIAGNOSTIC, PROGNOSTIC, RESPONSE PREDICTION BIOMARKERS, THERAPEUTIC INNOVATION, AND ECONOMIC ANALYSES IN CANCER

Description: This translational molecular research, supported by the Tumor Biobank, brings together a multidisciplinary group from fields such as medicine, biomedicine, chemistry, pharmaceutical sciences, veterinary medicine, mathematics, and statistics, among others, to study cancer with the aim of advancing prevention, diagnosis, and treatment.

Main Research areas: Therapeutic resistance markers; characterization of tumor microenvironments as targets for combined therapy and molecular imaging diagnosis in cancers; HPV-associated cancers; HPV immunology and vaccines; HPV molecular variants; viral transcription; gene therapy; extracellular vesicles and their diagnostic applications and as treatment vectors; therapeutic nucleic acids; predictive biomarkers of response in cancer; hereditary cancer; risk polymorphisms; economic evaluation studies in cancer; bioinformatics applied to precision oncology.

Researchers: Roger Chammas, Luisa Lina Villa, Maria Aparecida Azevedo Koike Folgueira, Maria Aparecida Nagai, Bryan Eric Strauss, Laura Cristina Sichero Vettorazzo, Miyuki Uno, Luciana Nogueira de Sousa Andrade, Luciana Barros Carvalho, Lara Termini, Alessandro Gonçalves Campolina

Contact: departamento.inrad@hc.fm.usp.br

1) PHYSICAL THERAPY IN CRITICALLY ILL PATIENTS

Description: The objectives of this research line are to investigate: 

i) physiotherapeutic interventions and their effects on the mobility and functionality of patients admitted to intensive care units, 

ii) the application of new technologies for the assessment and intervention in critical patients.

Main Research Areas: Physical Therapy, Intensive Care Unit, Mobilization, Rehabilitation

Researchers: Carolina Fu, Débora Stripari Schujmann Nogueira, Leda Tomiko Yamada da Silveira

Contact: fofito@usp.br

2) PULMONARY REHABILITATION, USE OF TECHNOLOGY IN HEALTH, ROLE OF PHYSICAL EXERCISE IN CARDIOPULMONARY DISEASES

Subject: Pulmonary Rehabilitation, Use of Technology in Health, Role of Physical Exercise in Cardiopulmonary Diseases

Description: These research lines have two objectives; 

- Investigate the effects of different interventions to improve the quality of life and clinical control of patients with cardiopulmonary diseases. Interventions include behavior change to increase physical activity, physical exercise, and respiratory exercises; and, 

- Develop technologies to improve the quality of life of patients, including the development of apps and software for diagnosis, home monitoring, and clinical treatment.

Main Research Areas: Rehabilitation/Respiratory Physiotherapy/Pulmonology/Cardiology

Researchers: Celso R F Carvalho, Adriana Cláudia Lunardi, Cibele Cristine Berto Marques, Regina Carvalho Pinto, Alberto Cukier, Marcelo Finger, Adílson Yuuri Hija, Elisa Yumi Nakagawa

Contact: fofito@usp.br

3) HAPTIC EVALUATION

Main Research Areas: Development of evaluation and testing tools with students and professionals in osteopathic manual therapy and neurology.

Researchers: Fátima Caromano, Leonardo Nascimento,Tatiane Petri, Juliana Rhein e Jéssica Câncido

Contact: fofito@usp.br

4) BIOMECHANICS, PREVENTION OF COMPLICATIONS AND REHABILITATION OF PEOPLE WITH DIABETES

Description: This research line aims to investigate different aspects of biomechanics in people with diabetes and neuropathy, evaluating changes in their musculoskeletal and sensory function, locomotor disabilities, and their consequences for daily life and health. The goal is also to prevent the formation of plantar ulcers and musculoskeletal dysfunctions, develop and test the effectiveness and economic cost of physiotherapeutic interventions for this population, and implement the most cost-effective strategies confirmed in the Unified Health System (SUS). Biomechanics, Diabetic Foot, Prevention.

Researchers: Isabel Sacco, Anice Pássaro, Ana Carolina Schmitt

Contact: fofito@usp.br

5) SPORTS AND PHYSICAL ACTIVITY/PHYSIOTHERAPY 

Description: The research project focuses on investigating the epidemiology, prevention, and treatment of injuries related to physical activity and sports. Its goals include understanding the extent of the problem, identifying risk factors and etiology, developing and evaluating preventive strategies, and implementing effective rehabilitation for injured individuals to safely return to sports.To achieve these goals, the project employs a variety of methods and techniques. These include quantitative studies like cross-sectional and longitudinal research, qualitative studies to understand individual experiences, mixed methods research combining quantitative and qualitative approaches, and health economic evaluations to assess cost-effectiveness. Additionally, the project utilizes tools and frameworks such as "Intervention Mapping," "RE-AIM," "Design Thinking," and "CFIR" to design, implement, and evaluate interventions effectively.

Main Research Areas: Epidemiology; Pain; Prevention of Sports Injuries; Dissemination and Implementation Science (D&I)

Researchers: Luiz Carlos Hespanhol Junior

Contact: fofito@usp.br

6) ELECTRO-PHYSICAL AGENTS AND PHYSIOTHERAPY IN OCCUPATIONAL HEALTH 

Subject: Electro-physical Agents and Physiotherapy in Occupational Health

Description: The objective of the Electro-physical Agents research line is to study the interaction of electrotherapy, thermotherapy, and phototherapy agents in animals and humans, evaluating indications, contraindications, and therapeutic effects. The Physiotherapy in Occupational Health line aims to evaluate the effect of ergonomic interventions on Worker Health.

Main resarch Areas: Agentes Eletrofísicos, Termoterapia, Fototerapia, Eletroterapia, Ergonomia, Saúde do Trabalhador

Researchers: Raquel Aparecida Casarotto

Contact: fofito@usp.br

7) ADOLESCENT IDIOPATHIC SCOLIOSIS 

Description: This research line aims to study Adolescent Idiopathic Scoliosis regarding screening and postural and musculoskeletal assessment.

Main Research Areas: Rehabilitation / Physical Therapy / Scoliosis

Researcher: Silvia Maria Amado João, Patrícia Jundi Penha, Ana Paula Carnevalli , Theodoros Grivas

Contact: fofito@usp.br

1. AUDIOLOGY

Description: The phenomena of hearing and its disorders are studied concerning the assessment of the nature and degree of impairment in auditory processing, conservation, and auditory rehabilitation of individuals with hearing loss. It involves clinical, experimental, geriatric, pediatric, and rehabilitation areas.

Main Research areas: Identification and Prevention of Auditory Risks, Evoked Auditory Potentials, Neuroaudiology, Human Hearing

Researchers: Alessandra Giannella Samelli, Carla Gentile Matas, Eliane Schochat, Renata Mota Mamede Carvallo

Contact: fofito@usp.br

2. SPEECH AND LANGUAGE

Description: The neural and motor systems responsible for intra and interpersonal communication are studied. This organized set of neuropsycholinguistic processes enables the reception, integration, and expression of information. This research line also includes aspects of speech related to voice production, motor skills, and oral functions.

Main Research areas: Fluency, facial functions, and dysphagia (Stuttering), Phonological development and its alterations, Health Promotion, Speech Therapy in Pediatrics (TDL), Neurological Disorders in Adults and the Elderly Voice Mental Health, Syndromes and Sensorimotor Alterations (Child Neuro)

Researchers: Claudia Regina Furquim de Andrade, Daniela Regina Molini Avejonas, Débora Maria Befi-Lopes, Haydée Fiszbein Wertzner, Mariangela Lopes Bitar, Nair Katia Nemr, Ana Paula Ritto

Contact: fofito@usp.br

1. OUTCOMES OF SURGICAL TREATMENT FOR LUNG CANCER AND OTHER THORACIC NEOPLASMS

Description: This research line aims to evaluate the clinical characteristics and analyze the anatomopathological factors associated with the prognosis of patients with thoracic and pulmonary neoplasms. It was structured for defining risk scores in various procedures related to the treatment of thoracic neoplasms, based on the construction of specific multicenter databases.

Main Research areas: Lung cancer; minimally invasive surgery; robotic surgery; artificial intelligence, surgical treatment; database.

Researchers: Paulo Manuel Pêgo Fernandes, Alberto Jorge Monteiro Dela Vega, Eserval Rocha Júnior, Fábio Eiti Nishibe Minamoto, Juliana Rocha Mol Trindade, Letícia Leone Lauricella, Michele Salati, Pedro Henrique Xavier Nabuco de Araujo, Ricardo Mingarini Terra.

Contact: departamento.cardiopneumo@incor.usp.br

2. DIAGNOSTIC AND CONTROL METHODS OF COMPLICATIONS IN CARDIOPULMONARY TRANSPLANTS

Description: This line includes clinical studies and experiments regarding the prevention and early diagnosis of complications related to primary graft dysfunction and rejection processes in heart and lung transplants

Main Research areas: Lung transplantation, ECMO, lung perfusion; biobank; experimental model of brain death; database.

Researchers: Paulo Manuel Pêgo Fernandes, Aristides Tadeu Correia, Flavio Pola dos Reis, Karina Andrighetti de Oliveira Braga, Liliane Moreira Ruiz, Lucas Matos Fernandes, Luis Gustavo Abdalla, Natalia Aparecida Nepomuceno, Paulo Francisco Guerreiro Cardoso, Rogerio Pazetti, Samuel Lucas dos Santos.

Contact: cardiopneumo@usp.br